Spike Transmission Delay at the Calyx of Held in vivo: Rate-dependence,

نویسندگان

  • Bernhard Englitz
  • Jonathan Scholbach
  • Jürgen Jost
  • Rudolf Rübsamen
چکیده

1 Phenomenological Modeling and Relevance for Sound Localization 2 3 Authors: Sandra Tolnai*, Bernhard Englitz*, Jonathan Scholbach, 4 Jürgen Jost, Rudolf Rübsamen 5 1 Institute of Biology II, University of Leipzig, Talstr. 33, 04103 Leipzig, Germany 6 2 Max Planck Institute for Mathematics in the Sciences, Inselstr. 22, 04103, Leipzig, Germany 7 3 Institute for Mathematics, University of Leipzig, 04109 Leipzig, Germany 8 * The authors contributed equally. 9 # present address: Department of Physiology, Anatomy and Genetics, University of Oxford, 10 Oxford OX1 3PT, United Kingdom 11 12 Abbreviated Title: Spike Transmission Delay at the Calyx of Held in vivo 13 14 15 16 Number of figures: 6 17 Number of pages: 43 18 Words in Abstract: 189 19 Words in Introduction: 521 20 Words in Discussion: 1682 21 22 Corresponding Author: Rudolf Rübsamen, Institute of Biology II, University 23 of Leipzig, Talstr. 33, D-04103 Leipzig, Germany, E-mail: rueb@uni24 leipzig.de, phone: +49 341 9736723 25 26 Acknowledgements: Financial support was provided by the DFG to RR (Ru 27 390-18/1). BE and ST were supported by the Graduate Program 28 INTERNEURO (GRK 1097) at the University of Leipzig. We thank M. Typlt 29 and R. Stollhoff for useful discussions and the anonymous reviewers for their 30 valuable comments. 31 32 Articles in PresS. J Neurophysiol (June 10, 2009). doi:10.1152/jn.00275.2009

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Spike transmission delay at the calyx of Held in vivo: rate dependence, phenomenological modeling, and relevance for sound localization.

Transmission at central synapses exhibits rapid changes in response amplitude under different patterns of stimulation. Whether the delay associated with the transmission of action potentials is similarly modifiable is important for temporally precise computations. We address this question at the calyx of Held of the medial nucleus of the trapezoid body (MNTB) in Mongolian gerbils in vivo using ...

متن کامل

How secure is in vivo synaptic transmission at the calyx of Held?

The medial nucleus of the trapezoid body (MNTB) receives excitatory input from giant presynaptic terminals, the calyces of Held. The MNTB functions as a sign inverter giving inhibitory input to the lateral and medial superior olive, where its input is important in the generation of binaural sensitivity to cues for sound localization. Extracellular recordings from MNTB neurons show complex spike...

متن کامل

Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome

The neurodevelopmental disorder Angelman syndrome (AS) is characterized by intellectual disability, motor dysfunction, distinct behavioral aspects, and epilepsy. AS is caused by a loss of the maternally expressed UBE3A gene, and many of the symptoms are recapitulated in a Ube3a mouse model of this syndrome. At the cellular level, changes in the axon initial segment (AIS) have been reported, and...

متن کامل

The calyx of Held develops adult-like dynamics and reliability by hearing onset in the mouse in vivo.

The development of the auditory system has received increasing attention since the mechanisms of patterned, spontaneous activity in prehearing mammals were discovered. This early activity originates in the cochlea and is assumed to be of importance for the establishment and refinement of synaptic connections in the auditory system. In the present study we investigate synaptic transmission and i...

متن کامل

A computational model of synaptic transmission at the calyx of Held

The calyx of Held is a giant glutamatergic synapse in the mammalian auditory pathway designed to ensure faithful transmission of high frequency action potential trains. Preand postsynaptic recordings from this synapse reveal several forms of facilitation and depression. A computational model of synaptic transmission has been developed to investigate the mechanisms underlying modulation at the c...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2009